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Injection Therapies for Pain: From Cortisone to PRP—What Works Best?
Injection Therapies for Pain: From Cortisone to PRP—What Works Best?

Whether it’s a nagging knee, stiff shoulder, or aching back, pain can hold you back from living fully, but effective relief may be closer than you think. Modern injection therapies offer targeted relief—reducing inflammation, stimulating tissue repair, and restoring movement without major surgery. Here’s a closer look at today’s most effective pain management injections and how they work.

Cortisone Injections: Rapid Inflammation Relief

Cortisone injections have long been a trusted tool for managing joint and soft tissue inflammation. They work by delivering a powerful anti-inflammatory steroid directly to the affected area, often the knee, shoulder, or spine. Relief usually begins within days and can last for weeks or months. However, repeated cortisone use may weaken tissues, so these injections are best used as part of a comprehensive treatment plan.

Hyaluronic Acid Injections: Smoother Joint Movement

Also known as “gel shots,” hyaluronic acid (HA) injections act as a lubricant within arthritic joints, especially the knees. HA helps reduce friction and improve mobility, allowing patients to move more comfortably. Results appear gradually and can last several months, making HA an appealing choice for those seeking nonsurgical solutions for osteoarthritis.

Platelet-Rich Plasma (PRP) and Cell Therapy: Regenerative Healing Options

Regenerative therapies like PRP and cell therapy harness your body’s natural ability to heal itself. PRP (platelet-rich plasma) therapy involves drawing a small sample of blood, concentrating the platelets, and injecting them into the injured area to stimulate tissue repair and reduce inflammation.

Cell therapy takes regeneration a step further by using cells derived from bone marrow or fat tissue to restore and strengthen damaged cartilage, ligaments, and tendons. These treatments don’t just mask pain, they promote healing at the cellular level. While results can take time to appear, many patients experience lasting improvement in pain, strength, and mobility.

Trigger Point Injections: Relief for Muscle Knots

For patients struggling with tight, painful muscles, trigger point injections can provide quick, targeted relief. These injections deliver a local anesthetic, sometimes with a small dose of steroid, directly into the tense muscle band, helping it relax and improving range of motion. They’re especially beneficial for myofascial pain in the neck, shoulders, or lower back.

Nerve Blocks and Facet Joint Injections: Targeted Spinal Pain Relief

Nerve blocks involve injecting anesthetic and anti-inflammatory medication near specific nerves to interrupt pain signals. They’re often used for conditions like sciatica, complex regional pain syndrome, or nerve compression. Facet joint injections, meanwhile, target the small joints in the spine that can cause chronic back or neck pain. Both procedures can relieve inflammation, confirm pain sources, and restore function without surgery.

Finding the Right Injection for Your Pain

The most effective injection depends on the source and severity of your pain, your activity level, and your long-term goals. Cortisone offers rapid relief, HA lubricates stiff joints, and regenerative options like PRP and cell therapy support true healing.

A detailed evaluation by an interventional pain management specialist can help determine which treatment is best suited to your condition. If pain is limiting your movement or daily comfort, book an appointment with Dr. Belamkar today to discover the injection therapy that can help you recover stronger and live more freely.

AUTHOR: Vinay C. Belamkar, MD, is the founder of Apollo Pain Center in Indianapolis with over a decade of experience exclusively in comprehensive pain care and fellowship in Interventional Pain Management, Anesthesia, and Internal Medicine, with a fellowship in spinal surgery. 

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